Ingredient Repository · Ingredient

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Ingredient

Diindolylmethane (DIM)

A plant compound from broccoli that supports healthy oestrogen balance and hormone clearance in men and women.

What it is

Diindolylmethane (DIM) is a natural plant compound created when your body digests cruciferous vegetables like broccoli, cabbage, and Brussels sprouts. In supplements, concentrated DIM is used to give you a consistent daily amount. It helps your liver process and balance hormone levels naturally.

Also known as: 3,3'-Diindolylmethane

Key benefits

  • Helps your body break down oestrogen into its protective form so your hormones stay balanced.
  • Supports healthy cells in hormone-sensitive tissues like breasts, prostate, and uterus.
  • Promotes smooth hormone metabolism so both women and men feel their best.

Amplified by probiotics

Your gut bacteria play a major role in how your body manages oestrogen. Friendly probiotics keep key digestive enzymes balanced so used oestrogen is flushed out rather than recycled back into your blood. Probiotics also produce natural fatty acids that soothe your gut lining and help your intestine absorb DIM smoothly, giving you full hormone support.

Typical dose

100–300 mg/day

The evidence

Evidence: moderate

Clinical studies show that taking DIM helps shift oestrogen breakdown toward healthier, protective forms in postmenopausal women. Human trials confirm that easy-to-absorb DIM preparations consistently support balanced hormone metabolism. (Castañeda-González 2022, Nutr Cancer) (Dalessandri 2004, Nutr Cancer)

  1. Castañeda-González LM, et al. Effectiveness of 3,3'-Diindolylmethane Supplements on Increasing Urinary 2/16α-Hydroxyestrone Ratio in Women: A Systematic Review. Nutr Cancer. 2022;74(9):3100-3110. PubMed ↗
  2. Dalessandri KM, et al. Pilot study: effect of 3,3'-diindolylmethane supplements on hormone metabolites in postmenopausal women with a history of early-stage breast cancer. Nutr Cancer. 2004;50(2):161-167. PubMed ↗

Safety & who should check first

DIM is well tolerated at normal amounts. It may cause a harmless dark colour in your urine as hormone by-products pass through. Speak to a doctor or pharmacist first if you are taking hormone treatments or oral contraceptives, and avoid taking DIM during pregnancy.